@article{136, keywords = {Azithromycin, Humans, Anti-Bacterial Agents, Child, Preschool, Infant, Gastrointestinal Microbiome, Macrolides, Burkina Faso}, author = {Catherine Oldenburg and Armin Hinterwirth and Ali Sie and Boubacar Coulibaly and Lucienne Ouermi and Clarisse Dah and Charlemagne Tapsoba and Susie Cummings and Lina Zhong and Cindi Chen and Samarpita Sarkar and Till Bärnighausen and Thomas Lietman and Jeremy Keenan and Thuy Doan}, title = {Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial.}, abstract = {

We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.

}, year = {2020}, journal = {Clin Infect Dis}, volume = {70}, pages = {525-527}, month = {2020 01 16}, issn = {1537-6591}, doi = {10.1093/cid/ciz455}, language = {eng}, }