@article{401,
  author = {John Gonzales and Miel Sundararajan and Ying Qian and Thomas Hwang and Thuy Doan},
  title = {Detection of Leptospirosis Genome from the Aqueous Humor of a Patient with Bilateral Uveitis.},
  abstract = {<p><b>BACKGROUND: </b>Leptospira species are difficult to culture. Thus, when there is suspicion for an infectious etiology to uveitis, bacterial cultures may fail to identify Leptospira. We describe a case of leptospirosis-associated uveitis that evaded culture and molecular assays. DNA sequencing of the aqueous fluid showed the presence of Leptospira spp.</p>

<p><b>METHODS: </b>Retrospective case review of clinical and laboratory features of a patient with ocular leptospirosis is presented.</p>

<p><b>RESULTS: </b>DNA sequencing identified the genome of Leptospirosis spp. in the aqueous humor.</p>

<p><b>CONCLUSION: </b>Metagenomic sequencing, by virtue of its unbiased nature, can be a helpful adjunctive test when a strong clinical suspicion for intraocular infection persists despite negative routine culture and molecular assays.</p>
},
  year = {2022},
  journal = {Ocul Immunol Inflamm},
  pages = {1-3},
  month = {2022 Apr 29},
  issn = {1744-5078},
  doi = {10.1080/09273948.2022.2067779},
  language = {eng},
}