@article{801,
  author = {Jessica Shantha},
  title = {Integrated metagenomic sequencing and phage display-based immunoprecipitation sequencing for presumptive viral infection: a case report.},
  abstract = {<p><b>PURPOSE: </b>To report a case of uveitis in which unbiased metagenomic sequencing (MDS) and phage immunoprecipitation sequencing (PhIP-Seq) were performed on intraocular fluid.</p><p><b>OBSERVATIONS: </b>A female patient with a past medical history of human immunodeficiency virus (HIV-1) who presented with chronic active anterior and intermediate uveitis with cystoid macular edema in the left eye. She had a previous ocular history of viral retinitis presumed to be secondary to cytomegalovirus (CMV). An anterior chamber tap was performed for viral polymerase chain reactions (PCRs), MDS, and pathogen PhIP-Seq. PCR testing and MDS were negative for pathogen genetic materials. PhIP-Seq detected antibody enrichment of CMV, as well as HIV-1 andSARS-CoV-2.</p><p><b>CONCLUSIONS: </b>The combination of MDS and PhIP-Seq has the potential to provide additional insights into the pathogenesis and the ocular microenvironment of uveitis patients.</p>},
  year = {2026},
  journal = {American journal of ophthalmology case reports},
  volume = {42},
  pages = {102561},
  month = {07/2026},
  issn = {2451-9936},
  doi = {10.1016/j.ajoc.2026.102561},
}