TY - JOUR
KW - AMR
KW - MORDOR
KW - Niger
KW - childhood mortality
KW - mass drug distribution
AU - Armin Hinterwirth
AU - Cindi Chen
AU - Daisy Yan
AU - Lina Zhong
AU - Zhaoxia Zhou
AU - YuHeng Liu
AU - Jeremy Keenan
AU - Kieran O'Brien
AU - Elodie Lebas
AU - Travis Porco
AU - Thomas Lietman
AU - Thuy Doan
AB - <p>The spread of antibiotic resistance is a major concern in the setting of azithromycin mass drug distribution for childhood mortality. We performed long-read whole-genome sequencing and phenotypic resistance analysis on  isolated from the nasopharynx of Nigerien children from communities treated with either six twice-yearly azithromycin distributions or placebo. Here, we showed that co-selection for macrolide, tetracycline, and trimethoprim-sulfamethoxazole genetic resistance was detected with repeated azithromycin mass drug distributions.CLINICAL TRIALSThis study is registered with ClinicalTrials.gov as NCT02047981.</p>
BT - Antimicrobial agents and chemotherapy
C1 - https://www.ncbi.nlm.nih.gov/pubmed/41432154
DA - 12/2025
DO - 10.1128/aac.01562-25
J2 - Antimicrob Agents Chemother
LA - eng
N2 - <p>The spread of antibiotic resistance is a major concern in the setting of azithromycin mass drug distribution for childhood mortality. We performed long-read whole-genome sequencing and phenotypic resistance analysis on  isolated from the nasopharynx of Nigerien children from communities treated with either six twice-yearly azithromycin distributions or placebo. Here, we showed that co-selection for macrolide, tetracycline, and trimethoprim-sulfamethoxazole genetic resistance was detected with repeated azithromycin mass drug distributions.CLINICAL TRIALSThis study is registered with ClinicalTrials.gov as NCT02047981.</p>
PY - 2025
EP - e0156225
T2 - Antimicrobial agents and chemotherapy
TI - Co-selection of genetic antibiotic resistance in  after repeated azithromycin mass drug administrations in Niger.
SN - 1098-6596
ER -