@article {726,
	title = {Multiple phosphorylation sites confer reproducibility of the rod{\textquoteright}s single-photon responses.},
	journal = {Science},
	volume = {313},
	year = {2006},
	month = {2006 Jul 28},
	pages = {530-3},
	abstract = {<p>Although signals controlled by single molecules are expected to be inherently variable, rod photoreceptors generate reproducible responses to single absorbed photons. We show that this unexpected reproducibility-the consistency of amplitude and duration of rhodopsin activity-varies in a graded and systematic manner with the number but not the identity of phosphorylation sites on rhodopsin{\textquoteright}s C terminus. These results indicate that each phosphorylation site provides an independent step in rhodopsin deactivation and that collectively these steps tightly control rhodopsin{\textquoteright}s active lifetime. Other G protein cascades may exploit a similar mechanism to encode accurately the timing and number of receptor activation.</p>
},
	keywords = {Animals, Arrestin, Electrophysiology, Mice, Mice, Transgenic, Models, Biological, Mutation, Patch-Clamp Techniques, Phosphorylation, Photons, Retinal Rod Photoreceptor Cells, Rhodopsin, Vision, Ocular},
	issn = {1095-9203},
	doi = {10.1126/science.1126612},
	author = {Doan, Thuy and Mendez, Ana and Detwiler, Peter B and Chen, Jeannie and Rieke, Fred}
}
