Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial.

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TitleEffect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial.
Publication TypeJournal Article
Year of Publication2022
AuthorsCoulibaly B, Kiemde D, Zonou G, Sie A, Dah C, Bountogo M, Brogdon J, Hu H, Lebas E, Porco TC, Doan T, Lietman TM, Oldenburg CE
JournalPediatr Infect Dis J
Volume41
Issue9
Pagination728-730
Date Published2022 Sep 01
ISSN1532-0987
Abstract

We evaluated antibiotic resistance selection in Streptococcus pneumoniae isolates from children participating in an individually randomized trial of single-dose azithromycin versus placebo. After 14 days, the prevalence of resistance to erythromycin, oxacillin, and clindamycin was elevated in the azithromycin versus placebo group. There was no difference at 6 months.

DOI10.1097/INF.0000000000003585
Alternate JournalPediatr Infect Dis J
PubMed ID35944061