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Comprehensive Analysis of Pathogens, Resistomes, and Inflammatory-markers in the CORNea

About the Study

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Infectious corneal ulcers affect all ages and contribute to significant visual morbidity worldwide. Empiric treatment with broad spectrum antimicrobials without regard for antimicrobial resistance is presently standard of care. This is either because pathogen identification with routine microbiological testing is suboptimal or testing is not done altogether. While empiric treatment is the preferred practice pattern for infectious keratitis worldwide, this is contrary to the goals and ideals of antimicrobial stewardship.

This study takes advantage of international collaborations and recent advances in genomic technologies to identify pathogens and provide regional AMR profiles to these infections. The results of this study may help to decrease AMR proliferation and improve diagnostics and therapeutic approaches for infectious keratitis, thus reducing the worldwide burden of corneal blindness.

Study Sites

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Site name Site Collaborators City Country
Blantyre Institute for Community Outreach Khumbo Kalua, MD, PhD Blantyre Malawi
Chulalongkorn University Vannarut Satipitakul, MD Bangkok Thailand
Cornea Associates of Texas Josh Zaffos, MD Dallas USA
Eyesight Hawaii Kristin Hirabayashi, MD; John Olkowski, MD Honolulu USA
Harkness Eye Institute, Columbia University Leejee Suh, MD New York USA
Instituto Mexicano de Oftalmología Charles Van Lansingh, MD, PhD; Jose Fernando Perez, MD; Ellery Lopez, MD Santiago de Querétaro Mexico
Moran Eye Center, University of Utah Amy Lin, MD Salt Lake City USA
Niger Ministry of Health, Programme National de Santé Oculaire Abdou Amza, MD, PhD Niamey Niger
Oregon Health and Science University Travis Redd, MD, MPH Portland USA
Pallas Kliniken Prof. Dr. Christoph Tappeiner; Prof. Dr. David Goldblum Olten Switzerland
Phramongkutklao Hospital Wiwan Sansanayudh, MD Bangkok Thailand
Price Vision Group Francis Price, MD;  Marianne Price, PhD Indianapolis USA
Rabin Medical Center Ruti Sella, MD; Lee Terner, MD Petah Tikva Israel
Singapore National Eye Center Jod Mehta, MD, PhD; Yu Chi Liu, MD Singapore Singapore
St John Eye Hospital & Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa Roland Höllhumer, MD Johannesburg South Africa
Sydney Eye Hospital Stephanie Watson, MD, PhD; Cabreras Aguas, MD Sydney Australia
Taipei Veterans General Hospital, Taipei, Taiwan Nai-Wen Fan, MD Taipei  Taiwan-Republic of China
University of California, Los Angeles: Stein Eye Center Simon Fung, MD, MA Los Angeles USA
University of California, San Diego: Shiley Eye Institute Esmeralda McClean, OD San Diego USA
University of California, San Francisco: Francis I Proctor Foundation See Study Team San Francisco USA
Universitätsklinikum des Saarlandes Berthold Seitz, MD; Tim Berger, MD; Loic Hamon, MD Homburg Germany
University of Wisconsin School of Medicine and Public Health Sarah Nehls, MD Madison USA


Study Team


Email: [email protected]