Comprehensive Analysis of Pathogens, Resistomes, and Inflammatory-markers in the CORNea
About the Study
Infectious corneal ulcers affect all ages and contribute to significant visual morbidity worldwide. Empiric treatment with broad spectrum antimicrobials without regard for antimicrobial resistance is presently standard of care. This is either because pathogen identification with routine microbiological testing is suboptimal or testing is not done altogether. While empiric treatment is the preferred practice pattern for infectious keratitis worldwide, this is contrary to the goals and ideals of antimicrobial stewardship.
This study takes advantage of international collaborations and recent advances in genomic technologies to identify pathogens and provide regional AMR profiles to these infections. The results of this study may help to decrease AMR proliferation and improve diagnostics and therapeutic approaches for infectious keratitis, thus reducing the worldwide burden of corneal blindness.
Study Sites
| Site name | Site Collaborators | City | Country |
|---|---|---|---|
| Blantyre Institute for Community Outreach | Khumbo Kalua, MD, PhD | Blantyre | Malawi |
| Chulalongkorn University | Vannarut Satipitakul, MD | Bangkok | Thailand |
| Cornea Associates of Texas | Josh Zaffos, MD | Dallas | USA |
| Eyesight Hawaii | Kristin Hirabayashi, MD; John Olkowski, MD | Honolulu | USA |
| Harkness Eye Institute, Columbia University | Leejee Suh, MD | New York | USA |
| Instituto Mexicano de Oftalmología | Charles Van Lansingh, MD, PhD; Jose Fernando Perez, MD; Ellery Lopez, MD | Santiago de Querétaro | Mexico |
| Maastricht University Medical Center | Mor M. Dickman, MD, PhD | Maastricht | Netherlands |
| Moran Eye Center, University of Utah | Amy Lin, MD | Salt Lake City | USA |
| Niger Ministry of Health, Programme National de Santé Oculaire | Abdou Amza, MD, PhD | Niamey | Niger |
| Oregon Health and Science University | Travis Redd, MD, MPH | Portland | USA |
| Pallas Kliniken | Prof. Dr. Christoph Tappeiner; Prof. Dr. David Goldblum | Olten | Switzerland |
| Phramongkutklao Hospital | Wiwan Sansanayudh, MD | Bangkok | Thailand |
| Price Vision Group | Francis Price, MD; Marianne Price, PhD | Indianapolis | USA |
| Rabin Medical Center | Ruti Sella, MD; Lee Terner, MD | Petah Tikva | Israel |
| Singapore National Eye Center | Jod Mehta, MD, PhD; Yu Chi Liu, MD | Singapore | Singapore |
| St John Eye Hospital & Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa | Roland Höllhumer, MD | Johannesburg | South Africa |
| Sydney Eye Hospital | Stephanie Watson, MD, PhD; Cabreras Aguas, MD | Sydney | Australia |
| Taipei Veterans General Hospital, Taipei, Taiwan | Nai-Wen Fan, MD | Taipei | Taiwan-Republic of China |
| University of California, Los Angeles: Stein Eye Center | Simon Fung, MD, MA | Los Angeles | USA |
| University of California, San Diego: Shiley Eye Institute | Esmeralda McClean, OD | San Diego | USA |
| University of California, San Francisco: Francis I Proctor Foundation | See Study Team | San Francisco | USA |
| University of Wisconsin School of Medicine and Public Health | Sarah Nehls, MD | Madison | USA |
| Universitätsklinikum des Saarlandes | Berthold Seitz, MD; Tim Berger, MD; Loic Hamon, MD | Homburg | Germany |
| Visualiza Sociedad Anonima | Mario Renato Papa, MD | Guatemala City | Guatemala |
Study Team
- Thuy Doan, MD, PhD
- Gerami Seitzman, MD
- Thomas Lietman, MD
- Benjamin Arnold, PhD, MPH
- Travis Porco, PhD, MPH
- Benjamin Pinsky, MD, PhD (Stanford University)
- Armin Hinterwirth, PhD
- Michael Deiner, PhD
- Rachel Caspi, PhD (National Eye Institute)
- Kevin Ruder, BS
- Cindi Chen, MS
- Lina Zhong, BA
- Elodie Lebas, RN
- David Liu, BS
- Thomas Abraham, BS
- Emily Colby, BS
Contact
Email: [email protected]