| Title | Acute Keratoconjunctivitis Resulting From Coinfection With Avian Newcastle Virus and Human Adenovirus. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | N Prajna V, Lalitha P, Chen C, Zhong L, Lietman TM, Doan T, Seitzman GD |
| Journal | Cornea |
| Date Published | 2021 Sep 04 |
| ISSN | 1536-4798 |
| Abstract | PURPOSE: The aim of this study was to report a case of human keratoconjunctivitis caused by both Newcastle disease virus (NDV) and human adenovirus. METHODS: A 32-year-old-man presented with an acute unilateral keratoconjunctivitis that resolved with corneal scarring. On presentation, his conjunctival swab was collected for metagenomic sequencing. RESULTS: The highest number of pathogen sequencing reads in the conjunctival sample mapped to the NDV. The second highest number of reads mapped to human adenovirus. Confirmation testing with directed reverse-transcription polymerase chain reaction also identified NDV in the specimen. CONCLUSIONS: Newcastle conjunctivitis has not been reported for more than 40 years. Mixed infections, including zoonotic pathogens, may be more common than realized. |
| DOI | 10.1097/ICO.0000000000002853 |
| Alternate Journal | Cornea |
| PubMed ID | 34483275 |