Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial.

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TitleIndirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial.
Publication TypeJournal Article
Year of Publication2019
AuthorsOldenburg CE, Sie A, Coulibaly B, Ouermi L, Dah C, Tapsoba C, Bärnighausen T, Lebas E, Arzika AM, Cummings S, Zhong L, Lietman TM, Keenan JD, Doan T
JournalOpen Forum Infect Dis
Volume6
Issue3
Paginationofz061
Date Published2019 Mar
ISSN2328-8957
Abstract

Cohabiting children may share components of their intestinal microbiome. We evaluated whether receipt of azithromycin in one sibling confers changes to the intestinal microbiome in an untreated sibling compared with placebo in a randomized controlled trial. We found no evidence of an indirect effect of antibiotic use in cohabiting children. NCT03187834.
DOI10.1093/ofid/ofz061
Alternate JournalOpen Forum Infect Dis
PubMed ID30895203
PubMed Central IDPMC6420410
Grant ListK08 EY026986 / EY / NEI NIH HHS / United States
R25 MH083620 / MH / NIMH NIH HHS / United States