Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial.

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TitleGut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial.
Publication TypeJournal Article
Year of Publication2020
AuthorsOldenburg CE, Hinterwirth A, Sie A, Coulibaly B, Ouermi L, Dah C, Tapsoba C, Cummings SL, Zhong L, Chen C, Sarkar S, Bärnighausen T, Lietman TM, Keenan JD, Doan T
JournalClin Infect Dis
Volume70
Issue3
Pagination525-527
Date Published2020 01 16
ISSN1537-6591
KeywordsAnti-Bacterial Agents, Azithromycin, Burkina Faso, Child, Preschool, Gastrointestinal Microbiome, Humans, Infant, Macrolides
Abstract

We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.
DOI10.1093/cid/ciz455
Alternate JournalClin Infect Dis
PubMed ID31149703
PubMed Central IDPMC7456340
Grant ListR25 MH083620 / MH / NIMH NIH HHS / United States